You can play the game natively on a physical PlayStation 3 console. Note that GTA 4 is not part of the modern PS4 or PS5 backward compatibility programs.
Assumptions made:
If you have an Xbox One or Xbox Series X/S, the original Xbox 360 disc or digital version works via backward compatibility with improved frame rates. To help you find the best way to play, could you tell me: Gta4 Ps2 Iso Highly Compressed
disable your antivirus to extract a "highly compressed" ISO. You can play the game natively on a