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To prevent a psychedelic experience from destabilizing family relationships, it is crucial to apply a "systems-informed" clinical lens. This means assessing the potential impact on close relationships before, during, and after the experience. A 2025 conceptual article suggests that without adequate attention, changes initiated through psychedelic therapy may contribute to relational distress, role confusion, or the reinforcement of maladaptive dynamics.

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Another major contribution in 2025, "Suggested Guidelines for Applying a Systemic Lens to Psychedelic-Assisted Psychotherapy," outlines a 10-session protocol involving preparation, psilocybin administration, and integration, with sessions that include significant relational figures such as partners or family members. This approach incorporates several established family therapy frameworks, including: Another major contribution in 2025