At its core, House, M.D. is a reimagining of Sherlock Holmes. House lives at 221B, has a loyal friend in Dr. James Wilson (Watson), and uses deductive reasoning to solve "crimes" where the villain is a disease. Seasons 1-3: The Golden Era of the Original Team

The narrative opens with a feature-length exploration of institutional rehab.House attempts to manage his chronic pain without using narcotic pills.He returns to the hospital with a altered approach to management.The season culminates in long-awaited romantic development with Dr. Cuddy. Season 7: The Cost of Happiness

The domestic partnership of House and Cuddy dominates the narrative, alongside the introduction of the brilliant, quirky medical student Martha Masters (Amber Tamblyn).