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Krasnov V.S.
Pavlov First St. Petersburg State Medical University
Kolontareva Yu.M.
Novartis Pharma LLC
Siponimod: a new view at the therapy of secondary progressive multiple sclerosis
Krasnov VS, Kolontareva YuM. Siponimod: a new view at the therapy of secondary progressive multiple sclerosis. S.S. Korsakov Journal of Neurology and Psychiatry.
2021;121(7):124‑129. (In Russ.)
https://doi.org/10.17116/jnevro2021121071124
Siponimod is a selective modulator of sphingosine-1-phosphate (S1P) receptors of types 1 and 5, registered in the Russian Federation for the treatment of patients with secondary progressive multiple sclerosis (SPMS), regardless of the presence or absence of exacerbations. The effectiveness of the drug in comparison with placebo was demonstrated in patients with SPMS in the international clinical trial EXPAND (phase III). This review devotes actual problems in the treatment of patients with SPMS, discusses the pathophysiology of multiple sclerosis progression, describes the peripheral and central mechanisms of siponimod action and its differences from fingolimod. According to analysis of scientific literature experimental, clinical and neuroimaging data are presented, which could explain the reasons for the successful use of siponimod in patients with SPMS, taking into account the pathophysiological mechanisms of the development of progression and the mechanisms of drug action.
Pavlov First St. Petersburg State Medical University
Kolontareva Yu.M.
Novartis Pharma LLC
Received:
20.04.2021
Accepted:
04.06.2021
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Because the characters are tall, ensure you give your text blocks enough vertical line spacing (leading) so the lines do not visually bleed into one another. How to Find a Safe and Legitimate Free Download
Ideal for credit blocks or bold title treatments.
Use it for the main cover line ("WAR & PEACE") and layer a subtle drop shadow. The black weight holds ink very well on uncoated paper.
Avoid shady, ad-heavy "free font" aggregator sites that require you to click through multiple misleading download buttons or download .exe files. A legitimate font file will always download as a .TTF (TrueType Font), .OTF (OpenType Font), or a compressed .ZIP file containing those formats. Typography Tips: How to Style Super Condensed Black Fonts
Perfect for tight headlines where every millimeter counts.
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